Thomas R Lane Selected Research

pyronaridine

10/2022	Pyronaridine Protects against SARS-CoV-2 Infection in Mouse.
3/2021	Repurposing the Ebola and Marburg Virus Inhibitors Tilorone, Quinacrine, and Pyronaridine: In Vitro Activity against SARS-CoV-2 and Potential Mechanisms.
12/2020	Repurposing the Ebola and Marburg Virus Inhibitors Tilorone, Quinacrine and Pyronaridine: In vitro Activity Against SARS-CoV-2 and Potential Mechanisms.
10/2020	Repurposing Pyramax®, quinacrine and tilorone as treatments for Ebola virus disease.
1/2020	Pyronaridine tetraphosphate efficacy against Ebola virus infection in guinea pig.
11/2019	Repurposing the antimalarial pyronaridine tetraphosphate to protect against Ebola virus infection.
1/2018	The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase.

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Thomas R Lane Research Topics

Disease

5	Malaria 03/2021 - 01/2018
5	Infections 01/2021 - 01/2018
4	Ebola Hemorrhagic Fever 10/2020 - 01/2019
2	COVID-19 10/2022 - 01/2021
2	Human Influenza (Influenza) 03/2021 - 12/2020
2	Tuberculosis (Tuberculoses) 01/2019 - 01/2018
1	Myasthenia Gravis 01/2021
1	Alzheimer Disease (Alzheimer's Disease) 01/2021
1	Dementia (Dementias) 01/2021
1	Dengue (Dengue Fever) 01/2021
1	Nervous System Diseases (Neurological Disorders) 01/2021
1	Parkinson Disease (Parkinson's Disease) 01/2021
1	Poisoning 01/2021
1	Lewy Body Disease (Lewy Body Dementia) 01/2021
1	Coronavirus Infections 03/2020
1	Chordoma 01/2020
1	Chemical and Drug Induced Liver Injury 01/2020
1	Opportunistic Infections (Opportunistic Infection) 01/2019

Drug/Important Bio-Agent (IBA)

7	pyronaridineIBA 10/2022 - 01/2018
5	Pharmaceutical PreparationsIBA 01/2021 - 11/2019
4	Quinacrine (Mepacrine)IBA 03/2021 - 01/2019
4	Antiviral Agents (Antivirals)IBA 01/2021 - 11/2019
3	Tilorone (Tilorone Hydrochloride)IBA 03/2021 - 10/2020
2	ArtesunateIBA 10/2020 - 11/2019
1	AcetylcholinesteraseIBA 01/2021
1	Cholinergic Antagonists (Anticholinergics)IBA 01/2021
1	palbociclibIBA 01/2020
1	Phosphotransferases (Kinase)IBA 01/2020
1	AfatinibIBA 01/2020
1	vistusertibIBA 01/2020
1	XenobioticsIBA 01/2020
1	Drug CombinationsIBA 01/2020
1	Antimalarials (Antimalarial Agents)IBA 11/2019
1	CytokinesIBA 11/2019
1	Immunologic Factors (Immunomodulators)IBA 11/2019
1	ChemokinesIBA 11/2019
1	Rifampin (Rifampicin)FDA LinkGeneric 01/2018
1	DNA-Directed RNA Polymerases (RNA Polymerase)IBA 01/2018

Therapy/Procedure

2	Therapeutics 01/2020 - 01/2019